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To investigate the effect of γ-aminobutyric acid (GABA) on acute renal failure, we used a rat model of acute tubular necrosis induced by glycerol. After deprivation of water for 6h, the rats received an injection of 50% glycerol into the muscle of the rear limb at 10ml/kg body weight. GABA was then administered orally to the rats (100 or 500mg/kg body weight/day) once every 12h for 3 days. The rats...
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