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The release of a nonsteroidal antiinflammatory agent (NSAID), 1-methyl-5-p-toluoylpyrrole-2-acetic acid (Tolmetin), from different molecular weight (9000, 16 000 or 109 000) poly-d,l-lactide (PDLLA) microspheres was tested at two different storage times (one and 6 months), by measuring the drug transfer from loaded microspheres to void model membranes at temperatures above and below polymer glass...
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