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Key points
Life course changes in cardiovascular function in a non‐human primate have been comprehensively characterized.
Age‐related declines in normalized left ventricular stroke volume and cardiac output were found with corresponding decreases in biventricular ejection fractions and filling rates.
There were age‐related decreases in male and female baboon normalized left ventricular myocardial...
Key points
Rodent models of intrauterine growth restriction (IUGR) successfully identify mechanisms that can lead to short‐term and long‐term detrimental cardiomyopathies but differences between rodent and human cardiac physiology and placental‐fetal development indicate a need for models in precocial species for translation to human development.
We developed a baboon model for IUGR studies using...
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