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Late-phase airway hyperresponsiveness (AHR) in asthma is considered the event leading to persistent inflammation in the lungs, but the molecular mechanisms involved in this process are poorly understood.To examine the role of TNF-α in the development of a late AHR and airway inflammation in asthma.We established a murine model of asthma with not only biphasic AHR to methacholine but also airway eosinophilia...
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