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Inorganic arsenic has been classified as a carcinogen for humans (Group I). However, its transit across the human intestinal epithelium has not been characterized. Using Caco-2 cells, the thiol–redox balance and apparent permeability coefficients (P app ) for As(III) in the apical to basolateral (AP–BL) and basolateral to apical (BL–AP) direction were evaluated. After As(III) exposure, GSH-induced...
Foods and drinking water are the main sources of human exposure to inorganic arsenic [As(III) and As(V)]. After oral ingestion, the intestinal epithelium is the first barrier to absorption of these species. A human intestinal cell line (Caco-2) was used to evaluate cell retention and transport of As(III) (15.6–156.0μM) and/or As(V) (15.4–170.6μM). Cell monolayer integrity, cell viability, membrane...
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