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ScopeCurcumin (CUR) and its major metabolite hexahydro‐CUR were studied in Caco‐2 cells and in the Caco‐2 Millicell® system in vitro to simulate their in vivo intestinal metabolism and absorption in humans.
Methods and resultsAnalysis of the incubation medium and cell lysate showed that Caco‐2 cells reduce CUR to hexahydro‐CUR and octahydro‐CUR, and conjugate CUR and its reductive metabolites with...
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