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In addition to their hormonal activity, endocrine active compounds may have the potential to cause DNA adducts, oxidative DNA damage, and disturbances of the mitotic apparatus of the cell. They can therefore give rise to gene mutations as well as structural and numerical chromosomal aberrations in the same way as do chemical carcinogens. This genotoxic potential is independent of the hormonal activity...
Bisphenol A (BPA), a monomer of polycarbonate plastics and epoxy resins, has previously been reported to induce micronuclei containing whole chromosomes in Chinese hamster V79 cells. In the present study, the aneuploidogenic potential of BPA was investigated in cultured human AG01522C fibroblasts. In contrast to the known aneugens diethylstilbestrol (DES) and 17β-estradiol, which caused mitotic arrest...
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