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A series of 5‐(o‐tolyl)‐1H‐tetrazole derivatives were synthesized and evaluated for their anticonvulsant activities. 1‐(2‐Methylbenzyl)‐5‐(o‐tolyl)‐1H‐tetrazole (3h) showed important anticonvulsant activity against the MES‐induced seizures, as well as lower neurotoxicity with an ED50 value of 12.7 mg/kg and a TD50 value of over 500 mg/kg after intraperitoneal injection into mice, providing 3h with...
A series of 5‐substituted benzo[d][1,3]dioxole derivatives was designed, synthesized, and tested for anticonvulsant activity using the maximal electroshock (MES) and subcutaneous pentylenetetrazole (scPTZ) screens. Neurotoxicity was determined by rotarod test. In the preliminary screening, six compounds, 3a, 3c, 3d, and 4d–f, showed promising anticonvulsant activities in the MES model, and compounds...
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