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Transforming growth factor β (TGF β) family members are secreted in inactive complexes with a latency-associated peptide (LAP), a protein derived from the N-terminal region of the TGF β gene product. Extracellular activation of these complexes is a critical but incompletely understood step in regulation of TGF β function in vivo. We show that TGF β 1 LAP is a ligand for the integrin α vβ 6 and that...
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