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The impregnation of ibuprofen into submicron films (25–250nm) of poly(methyl methacrylate), PMMA, under supercritical CO 2 conditions (at 40°C and 50°C and 13.8 and 20.7MPa) was studied. The quartz crystal microbalance (QCM) was used to perform real-time, in situ impregnation measurements. The amount of ibuprofen uptake into the polymer film was calculated directly from the QCM results. Different...
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