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Asymmetric methods for preparation of chiral alkynyl‐containing compounds are in extremely high demand in many sectors of chemical research. In this work, we report the discovery of a general organocatalytic enantioselective alkynylation based on the idea of Si/F activation of the allylic C−F bond. This approach features reasonably broad substrate scope, functional group tolerance, and relatively...
Es gehören vier dazu: Die Titelreaktion gelang erstmals mit einem aus vier Komponenten bestehenden Katalysatorsystem, ZnII/Box‐Ph/Yb(OTf)3/HFIP, und lieferte die Produkte in hohen Ausbeuten und Enantioselektivitäten. Die Fluorierung eines der Produkte mit Selectfluor bietet effizienten Zugang zu einem medizinisch relevanten Allylfluorid. Box‐Ph=2,2′‐Isopropylidinbis(4‐phenyl‐2‐oxazolin), HFIP=Hexafluorisopropylalkohol.
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