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The difunctional substrate 2,4-dibromothiazole 2 was transformed into the title compounds 1 by consecutive Pd(0)-catalyzed cross-coupling reactions. Aryl zinc reagents which were prepared by ortho-lithiation of compounds 3 and subsequent transmetalation were used as carbon nucleophiles in the first coupling reaction. By this means, an aryl substituent was attached to the 2-position (50-62% yield)...
The nitrene transfer from t-Butyloxycarbonyl azide (BocN 3 ) to several nucleophiles is promoted by ferrous chloride (FeCl 2 ) and yields the corresponding N-Boc protected sulfoximides, sulfimides, or a-amino alkanoates. Whereas the sulfoximide formation occurs spontaneously in CH2C12 as solvent the FeCl2-catalyzed nitrene transfer to sulfides and ketene acetals requires addition of...
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