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Functional ISFET devices for the specific analysis of the NAD(P) + -cofactors are described. The functional ISFET devices consist of a pyrroloquinoline quinone (PQQ)-modified gate, to which the NAD(P) + -dependent enzymes, lactate dehydrogenase, LDH (for NAD + analysis), or alcohol dehydrogenase, AlcDH (for NADP + analysis), are covalently linked. In the presence of...
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