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Outersphere electron transfer in multicopper oxidases occurs at the type 1, blue Cu II . One class of MCO proteins exhibits a specificity in this reaction towards Fe II . In work carried out in collaboration with the Solomon lab over the past 7 years, we have delineated the structural motifs that support this ferroxidase specificity and have quantified the contributions that each makes...
The Fet3 protein in Saccharomyces cerevisiae and mammalian ceruloplasmin are multicopper oxidases (MCO) that are required for iron homeostasis via their catalysis of the ferroxidase reaction, 4Fe 2+ +O 2 +4H + ->4Fe 3+ +2H 2 O. The enzymes may play an essential role in copper homeostasis since they exhibit a strikingly similar kinetic activity towards...
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