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Patients with bone cancer report severe pain and receive μ-opioids. We developed a family of peptidomimetic δ-agonists, one of which H 2 N-Tyr-dVal-Gly-Phe-Ala-OH ([dValL2,AlaL5]E) binds with a 1700× affinity at the δ versus μ receptor. To examine the systemic analgesic efficacy of this δ-agonist versus morphine in osteosarcoma pain, osteosarcoma cells are injected into one femur of the anesthetized...
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