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Triapine (Tp) is an iron chelator with activity against several types of cancer. Iron–Tp [Fe(III)(Tp) 2 ] can be redox-cycled to generate reactive oxygen species that may contribute to its cytotoxicity. However, evidence for this mechanism in cells is limited. The cytosolic and mitochondrial thioredoxins (Trx1 and Trx2, respectively) are essential for cell survival. They are normally maintained...
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