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Mittels Biokonjugationschemie können modifizierte Biomoleküle hergestellt werden, deren Funktionsumfang das natürliche Maß übersteigt. Hierbei ist die Entwicklung hocheffizienter und selektiver Biokonjugationsreaktionen von Bedeutung, die unter milden, biokompatiblen Bedingungen ablaufen. Vielversprechend sind hierbei Verfahren, bei denen Bindungen zwischen einem Nukleophil und einem sp2‐hybridisierten...
A mild method for the arylation of lysine in an unprotected peptide is presented. In the presence of a preformed biarylphosphine‐supported palladium(II)–aryl complex and a weak base, lysine amino groups underwent C−N bond formation at room temperature. The process generally exhibited high selectivity for lysine over other amino acids containing nucleophilic side chains and was applicable to the conjugation...
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