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Die Radiomarkierung von Arenen mit [18F]Fluorid beschreiben V. Gouverneur et al. in der Zuschrift auf S. 7885 ff., die dazu ein Verfahren mit einfach zugänglichen Arylboronsäureestern als Vorstufen nutzen. Im Bild wird – im beschränkten Raum eines PET‐Scanners (PET: Positronenemissionstomographie) – die Auslöschung illustriert, die aus der Positronenemission aus [18F]Fluor‐L‐DOPA resultiert.
Molecules labeled with fluorine‐18 are used as radiotracers for positron emission tomography. An important challenge is the labeling of arenes not amenable to aromatic nucleophilic substitution (SNAr) with [18F]F−. In the ideal case, the 18F fluorination of these substrates would be performed through reaction of [18F]KF with shelf‐stable readily available precursors using a broadly applicable method...
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