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Substantive evidence implicates vitamin D receptor (VDR) or its natural ligand 1α,25-(OH) 2 D 3 in modulation of tumor growth. However, both human and animal studies indicate tissue-specificity of effect. Epidemiological studies show both inverse and direct relationships between serum 25(OH)D levels and common solid cancers. VDR ablation affects carcinogen-induced tumorigenesis in...
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