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A series of nickel complexes, 1b–3b, exhibiting subdued cytotoxicity have been designed with the intent of their use as agents for developing resistance to nickel toxicity. Indeed, the nickel complexes, 1b–3b, display less cytotoxic activity towards two commonly occurring human cancer cell lines namely, HeLa cells (16–64%) and MCF-7 cells (70–90%) in culture as compared to the maximum inhibition by...
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