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Objective and design Renal ischemia–reperfusion (IR)-induced acute kidney injury (AKI) remains a major challenge in clinic. The histone methyltransferases enhancer of zest homolog-2 (EZH2) is associated with the development of renal injury. However, the molecular mechanism has not been fully elucidated. Materials AKI in C57BL/6 mice was generated by renal IR. Treatments The 3-deazaneplanocin A...
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