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To evaluate the effects of mifepristone (RU486) on the development of uterine adenomyosis induced by pituitary grafting (PG), 3 groups of mice receiving pituitary grafts at 7 weeks of age were given RU486 in food (20mg/kg chow) from 3-14 (RU486-3 group) or 10-14 (RU486-10 group) weeks of age, or were given no further treatment (PG control group), respectively. All the mice were killed at 14 weeks...
Transplacental exposure to diethylstilbestrol (DES) causes morphological and functional changes including the disruption of follicular maturation in murine ovaries. Since the function of ovarian sympathetic nerves is thought to be related to the follicular maturation, we examined changes in the distribution pattern of the sympathetic nerves between prenatally DES-exposed rat ovaries and normal controls...
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