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5-Lipoxygenase (5-LO) is a key enzyme involved in the synthesis of leukotrienes from arachidonic acid, and its activation is usually followed by translocation to the nuclear envelope. The details of mechanisms involved in the translocation of 5-LO are not well understood, though Ca 2+ is known to be essential. Here we show that ionomycin, a Ca 2+ ionophore, induces 5-LO translocation...
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