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Background
The mechanisms by which genetic and environmental factors interact to promote asthma remain unclear. Both the IL‐4 receptor alpha chain R576 (IL‐4RαR576) variant and Notch4 license asthmatic lung inflammation by allergens and ambient pollutant particles by subverting lung regulatory T (Treg) cells in an IL‐6‐dependent manner.
Objective
We examined the interaction between IL‐4RαR576 and...