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Inhibition of NF-κB transcriptional activity by steroid receptors is the basis for the antiinflammatory actions of steroid hormones and the molecular mechanism underlying this cross-talk is thought to involve direct protein–protein interactions. In this study, we show that estrogen receptor (ER)α and NF-κB interact in vivo by using fluorescence resonance energy transfer (FRET) and co-immunoprecipitation...
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