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Background: Valvuloseptal defects are the most common congenital heart defects. Notch signaling–induced endothelial‐to‐mesenchymal transition (EMT) in the atrioventricular canal (AVC) cushions at murine embryonic day (E)9.5 is a required step during early valve development. Insights to the transcriptional network that is activated in endocardial cells (EC) during EMT and how these pathways direct...
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