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The transmembrane conformation of Thermotoga maritima CorA, a magnesium transport system, has been studied in its Mg 2+ -bound form by site-directed spin labeling and electron paramagnetic resonance spectroscopy. Probe mobility together with accessibility data were used to evaluate the overall dynamics and relative arrangement of individual transmembrane segments TM1 and TM2. TM1 extends toward...
Ionotropic glutamate receptors are ligand-gated transmembrane ion channels activated by the binding of glutamate. The free energy landscapes governing the opening/closing of the GluR2 S1S2 ligand-binding domain in the apo, DNQX-, and glutamate-bound forms are computed by using all-atom molecular dynamics simulations with explicit solvent, in conjunction with an umbrella sampling strategy. The apo...
Membrane depolarization causes voltage-gated ion channels to transition from a resting/closed conformation to an activated/open conformation. We used voltage-clamp fluorometry to measure protein motion at specific regions of the Shaker Kv channel. This enabled us to construct new structural models of the resting/closed and activated/open states based on the Kv1.2 crystal structure using the Rosetta-Membrane...
Potassium channels are tetrameric membrane-spanning proteins that provide a selective pore for the conduction of K + across the cell membranes. One of the main physiological functions of potassium channels is efficient and very selective transport of K + ions through the membrane to the cell. Classical views of ion selectivity are summarized within a historical perspective, and contrasted...
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