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Mycobacterium tuberculosis synthesizes a thick cell wall comprised of mycolic acids (MA), which are foreign antigens for human T cells. T‐cell clones from multiple donors were used to determine the fine specificity of MA recognition by human αβ T cells. Most CD1‐presented lipid antigens contain large hydrophilic head groups comprised of carbohydrates or peptides that dominate patterns of T‐cell specificity...
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