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An ongoing strategy for cancer treatment is selective induction of apoptosis in cancer over normal cells. N-thiolated β-lactams were found to induce DNA damage, growth arrest and apoptosis in cultured human cancer cells. However, whether these compounds have a similar effect in vivo has not been studied. We report here that treatment with the β-lactam L-1 caused a significant inhibition of tumor growth...
Historically, it has been shown that the β-lactam antibiotics play an essential role in treating bacterial infections while demonstrating selectivity for prokaryotic cells. We recently reported that certain N-methylthio-substituted β-lactam antibiotics had DNA-damaging and apoptosis-inducing activities in various tumor cells. However, whether these compounds affect human normal or nontransformed cells...
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