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The preparation method for the surface zinc-modified hydroxyapatite particles that we developed as immobilized metal ion affinity chromatography medium, required decantation process to remove the excess zinc ion. Therefore, large-scale production was sometimes difficult because of this process. In this report, we describe our improved method to synthesize zinc-substituted hydroxyapatite (CaZnHAp)...
Polyethylenimine (PEI) has been widely used as a coating material to produce stationary phase for ion-exchange chromatography of biomolecules. However, a precise study of the PEI coating fraction has been lacking, despite such quantification being very important for fundamental research as well as identifying further industrial applications.In this study, we produced four types of PEI-coated hydroxyapatite...
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