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The potentiation of central cholinergic activity has beenproposed as a therapeutic approach for improving cognitivefunction in patients with Alzheimer's disease. Increasingthe acetylcholine concentration in brain by modulatingacetylcholinesterase (AChE) activity is among the mostpromising strategies. We have used a combinatorial approachto identify different 2,5-piperazinediones (DKP) with AChEinhibitory...
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