The Infona portal uses cookies, i.e. strings of text saved by a browser on the user's device. The portal can access those files and use them to remember the user's data, such as their chosen settings (screen view, interface language, etc.), or their login data. By using the Infona portal the user accepts automatic saving and using this information for portal operation purposes. More information on the subject can be found in the Privacy Policy and Terms of Service. By closing this window the user confirms that they have read the information on cookie usage, and they accept the privacy policy and the way cookies are used by the portal. You can change the cookie settings in your browser.
The metabolism of several tachykinin antagonists by membrane peptidases has been examined. [βAla 8 ]NKA (4-10) was not stabilized against degradation by endopeptidase-24.11 and this was the major activity in renal brush border membranes hydrolyzing this peptide. The antagonist MEN 10263 was much more resistant to hydrolysis by endopeptidase-24.11, although hydrolysis of the C-terminal Leu-Phe...
Endopeptidase-24.11 ('enkephalinase', EC 3.4.24.11) from pig kidney hydrolysed neurokinin B at 4 sites:The major site of hydrolysis was the Gly 8 -Leu 9 bond. Angiotensin converting enzyme (peptidyl dipeptidase A, EC 3.4.15.1) from pig kidney hydrolysed substance P releasing the C-tenninal tripeptide Gly-Leu-MetNH 2 but failed to hydrolyse neurokinin B. Pig brain striatal synaptic...
Endopeptidase-24.11 (EC 3.4.24.11) from pig kidney hydrolysed CCK-8 (sulphated) at two distinct sites: Asp-Tyr(SO 3 H)-Met-Gly↓Trp-Met-Asp↓PheNH 2 . Under initial conditions, the splitting of the Asp 7 -Phe 8 NH 2 bond proceeded 4-times more rapidly than the Gly 4 -Trp 5 bond. Pig brain striatal synaptic membranes attacked this substrate at the...
Set the date range to filter the displayed results. You can set a starting date, ending date or both. You can enter the dates manually or choose them from the calendar.