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The molecular basis of priming for l-DOPA-induced dyskinesias in Parkinson's disease (PD), which depends on the indirect pathway of motor control, is not known. In rodents, the indirect pathway contains striatopallidal GABAergic neurons that express heterotrimers composed of A 2A adenosine, CB 1 cannabinoid and D 2 dopamine receptors that regulate dopaminergic neurotransmission...
Adenosine A 2A receptor (A 2A R) antagonists are being investigated as promising treatment strategy for Parkinson's disease (PD). To test whether A 2A R antagonists are beneficial in early PD stages we used MitoPark mice, a genetic model with gradual degeneration of DA cells. Daily treatment of young MitoPark mice for eight weeks with the A 2A R antagonist MSX-3 prevented...
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