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The coronavirus disease‐19 (COVID‐19) pandemic has raised major interest in innovative drug concepts to suppress human coronavirus (HCoV) infections. We previously reported on a class of 1,2,3‐triazolo fused betulonic acid derivatives causing strong inhibition of HCoV‐229E replication via the viral nsp15 protein, which is proposedly related to compound binding at an intermonomer interface in hexameric...
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