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A practical procedure for catalytic asymmetric synthesis of optically active arylglycine derivatives via optically active α-aminonitriles has been developed. The N-benzhydryl α-arylaminonitrile intermediates were prepared in excellent yield (89–99%) and enantiomeric purity (96 to >98% ee) by enantioselective cyanation of aldimines with TMSCN/ i PrOH in the presence of 2.5mol% of an easily...
N-salicyl-β-amino alcohols 1 were synthesized and evaluated as ligands for catalytic asymmetric Strecker reactions. N-Benzhydrylaldimines derived from aromatic and aliphatic aldehydes reacted with TMSCN in the presence of 10mol% of Ti-1 complex to give the Strecker products in excellent yields and in up to >98% ee. The presence of a protic additive is essential to ensure good conversion and reaction...
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