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A weakly acidic pH‐responsive polypeptide is believed to have the potential for an endosome escape function in a polypeptide‐triggered delivery system. For constructing a membrane fusion device with pH‐responsiveness, we have designed novel polypeptides that are capable of forming an α2 coiled coil structure. Circular dichroism spectroscopy reveals that a polypeptide, AP‐LZ(EH5), with a Glu and His...
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