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There is an urgent unmet medical need for new treatments for wound and burn infections caused by multidrug‐resistant Gram‐negative “superbugs,” especially the problematic Pseudomonas aeruginosa. In this work, the incorporation of colistin, a potent lipopeptide into a self‐healable hydrogel (via dynamic imine bond formation) following the chemical reaction between the amine groups present in glycol...
A novel PEGylated biodegradable hyperbranched PEG‐b‐PDMAEMA has been synthesized. The low toxicity, small molecular weight PDMAEMA chains were crosslinked using a biodegradable disulfide‐based dimethacrylate (DSDMA) agent to yield higher molecular weight hyperbranched polymers. PEG chains were linked onto the polymer surface, masking the positive charge (as shown by Zeta potential measurements) and...
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