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A facile enzymatic one-pot multicomponent synthesis of 4-thiazolidinones was developed. The trypsin from porcine pancreas displayed great catalytic activity to promote the reaction of aldehyde, amine and mercaptoacetic acid with high yields showing a broad substrate specificity in this reaction. This trypsin-catalyzed multicomponent conversion method provided a novel strategy to synthesize thiazolidinones...
A new mild enzymatic methodology for synthesizing quinoline derivatives by Friedländer condensation was developed. A series of quinoline derivatives were synthesized and characterized by 1H NMR, 13C-NMR, IR and MS. The probable enzymatic mechanism was proposed. It provides a novel method to prepare quinoline derivatives. Graphical Abstract
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