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In nanofibers composed of self‐assembling helical peptides, “capping” peptides can limit fiber growth and influence the character of immune responses raised by the materials. In article number 2003310, Joel H. Collier and co‐workers design short peptides such that they self‐assemble into immunologically active helical nanofibers. The lengths of these fibers, tailorable by the incorporation of structure‐modifying...
Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fiber lengths and an incomplete understanding of how nanofiber length affects biological responses. Here, rationally designed capping peptides control...
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