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Here we report that budding yeast mitochondrial DNA protects against salt stress-induced apoptosis. Yeast cells lacking mitochondrial DNA (ρ 0 ) are hypersensitive to salt stress-induced apoptosis, which is mediated by mitochondrial cytochrome c release. In addition, cytochrome c expression is downregulated upon salt stress, suggesting a transcriptionally regulated, homeostatic protection...
Pds5p is a cohesin related protein. It is required for maintenance of sister chromatid cohesion in mitosis and meiosis. Here we report that pds5-1 causes cell death in yeast Saccharomyces cerevisiae during early meiosis. The pds5-1 caused cell death possesses characteristics of apoptosis and necrosis, including externalization of phosphatidylserine at cytoplasmic membrane, accumulation of DNA breaks,...
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