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INTRODUCTION:A copolymer of the partially quaternized poly(tertiary amine)-type, Q-P(TDAE)x, has been proposed for molecular encapsulation and pH-induced release of hydrophobic drugs. With decreasing pH, this polymer changes its conformation from globular to extended, then releasing the entrapped drugs. Unfortunately, intravenous injection to small animals caused cardiovascular distress. In order...
INTRODUCTION:A polycationic polymer is studied as a carrier system for the administration of hydrophobic drugs. Conformational changes of this macromolecule, from globular to extended form depending on the pH, lead to the release of entrapped drugs only in specific tissues with low pH. This polymer is thus an interesting candidate for tumor targeting of anticancer drugs. Moreover, it could be used...
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