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This article reviews results on the studies of biomedical applications of functional polymers in which biologically active compounds are chemically or physically immobilized. The strategy for achieving of biological activity of polymers, the designs of them, polymers syntheses, and biological and biomedical examinations are discussed. As polymeric anticancer drugs polymeric prodrugs having 5-fluorouracil...
Poly(amino acid)s have received considerable attention for biomedical applications. Poly(γ-glutamic acid) (γ-PGA), a natural polymer, is synthesized by several gram-positive bacteria. γ-PGA is anionic, water soluble, biodegradable, edible, nontoxic, and nonimmunogenic for humans and the environment, and its α-carboxylate side chains can be chemically modified to introduce various drugs, or to modulate...
This paper reports the mechanical properties of 3D layered tissue were measured by using a special fixture (micro vacuum chuck) and a measurement system. In this study, the mechanical properties of 3D layered tissue were measured by tensile test. Since difficulty of fixing the 3D layered tissue to tensile test system, the micro vacuum chuck which could fix the 3D layered tissue to tensile test system...
The layer-by-layer films of nanometer-sized extracellular matrix were fabricated on cell surfaces to develop multilayered cellular constructs involving blood and lymph capillary networks for tissue engineering and pharmaceutical applications.
This chapter demonstrates several approaches for innovative three‐dimensional (3D) tissue fabrications by employing layer‐by‐layer (LbL) nanofilms constructed through biological recognition. It discusses how the 3D tissues could contribute to understanding pathophysiological and pharmaceutical events. Currently, various methodologies such as cell sheet engineering, the cell beads method, and magnetic...
We proposed a fabrication technique of tubular tissues as an artery and the circulatory culture system for evaluating the development mechanisms of them. The tubular tissues were 2–6 mm in diameter, using a poly (L-lactide-co-ipusironn-caprolactone) (PLCL) scaffold. They consisted of the cell membranes and the PLCL scaffolds. Moreover, these tubular tissues had a mechanical property of artery because...
We proposed a 3D assembly technique using water transfer printing to fabricate a multilayer structured tubular tissue. This study was aimed to determine whether the tissue-engineered tubular structure maintains the normally mechanical property as the development and function by the artificial circulatory system. In this work, we demonstrated that fabricated tissues could rapidly assemble into aligned...
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