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Background
Antiandrogens are effective therapies that block androgen receptor (AR) transactivation and signaling in over 50% of castration‐resistant prostate cancer (CRPC) patients. However, an estimated 30% of responders will develop resistance to these therapies within 2 years. JNJ‐pan‐AR is a broad‐spectrum AR antagonist that inhibits wild‐type AR as well as several mutated versions of AR that...
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