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DNA detection is usually conducted under nondenaturing conditions to favor the formation of Watson–Crick base‐paring interactions. However, although such a setting is excellent for distinguishing a single‐nucleotide polymorphism (SNP) within short DNA sequences (15–25 nucleotides), it does not offer a good solution to SNP detection within much longer sequences. Here we report on a new detection method...
A molecular switch for ultra‐specific detection of DNA utilizing a guanine‐quadruplex (top‐right structure) resistant to denaturation by urea (ball‐and‐stick structures) is depicted in the surrealist cover artwork. The contrasting halves of the background along with colored balls represent the versatility of the switch: the red balls on the dark half represent fluorescence sensing with protoporphyrin...
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