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Resistance to antimicrobial agents has been recognized since the dawn of the antibiotic era. Paul Ehrlich, the father of modern chemotherapy, observed that, during treatment of trypanosome infections, organisms sometimes emerged that were resistant to the agent being used. Resistance was specifi c in the sense that a fuchsin dye-resistant strain was still susceptible to an arsenic compound, while...
In the 1990s quinolone resistance increased in parallel with increased quinolone utilization (1) and also with the emergence of plasmid-mediated quinolone resistance. The fi rst type of plasmid-mediated resistance was discovered in a clinical strain of Klebsiella pneumoniae isolated at the University of Alabama in 1994 that transferred low-level quinolone resistance along with resistance to several...
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