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Very recently, the mouse 17α-hydroxysteroid dehydrogenase (m17α-HSD), a member of the aldo-keto reductase (AKR) superfamily, has been characterized and identified as the unique enzyme able to catalyze efficiently and in a stereospecific manner the conversion of androstenedione (Δ4) into epitestosterone (epi-T), the 17α-epimer of testosterone. Indeed, the other AKR enzymes that significantly reduce...
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