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17β-Estradiol (17β-E2) augments VEGF-A expression in various estrogen targeted organs and cells including breast tumor derived cell lines, via an ER-α mediated pathway. Ironically, 17β-E2 is able to regulate some genes via ER-α independent pathways. In the present study, we sought to determine whether 17β-E2 can modulate VEGF-A expression in absence of ER-α, and therefore, three different cell lines...
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