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Carbocyclic-2 ,3 -didehydro-2 ,3 -dideoxyguanosine is the parent compound in a series of 6-substituted-2-amino purine carbocyclic nucleosides (called carbovir, CVR) that are potent and selective inhibitors of human immunodeficiency virus [Vince et al., BBRC 156: 1046, 1988; Vince and Hua, US patents 4,916,224, 4,931,559, 4,950,758, (1990)].We have identified the active CVR enantiomer, characterized...
4 -Thiothymidine (S-dThd) is a potent inhibitor of L1210 cell growth and is active against P388 leukemia in mice. Because of these activities and its novel structure, we have begun studies of its metabolism and metabolic actions in L1210 cells in order to understand its mechanism of cytotoxicity. S-dThd inhibited the incorporation of radiolabeled precursors into DNA, but did not inhibit the incorporation...
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