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Cancer cells are highly dependent on methionine and cystine (Met–Cys) for survival and proliferation. However, the molecular mechanism is not fully clear. The present study is to investigate the effects of Met–Cys deprivation on glioma cells proliferation. The results showed that Met–Cys double deprivation had synergistic action on elevating ROS level, decreased GSH level and inhibition of glioma...
Notch signaling has been demonstrated to have a central role in cancer stem-like cells (CSLCs) in glioblastoma multiforme (GBM). We have recently demonstrated the inhibitory effect of arsenic trioxide (ATO) on CSLCs in glioblastoma cell lines. In this study we used neurosphere recovery assay that measured neurosphere formation at three time points to assess the capacity of the culture to repopulate...
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