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The Xenopus laevis oocyte expression system was used to determine the activities of α-conotoxins EpI and the ribbon isomer of AuIB, on defined nicotinic acetylcholine receptors (nAChRs). In contrast to previous findings on intracardiac ganglion neurones, α-EpI showed no significant activity on oocyte-expressed α3β4 and α3β2 nAChRs but blocked the α7 nAChR with an IC50 value of 30 nM. A similar IC50...
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